Upon this title, Steve Savage, a blogger about agriculture and technology, gives the example of the quality vineyard in California. This is an example. But the dramatic changes he describes is similar in other crops and other regions.
His main and most detailed arguments in his article are about the history of acute toxicity of pesticides, compared to natural common substances, and the history of the uses of pesticides.
Definitely, nowadays, pesticides are “much safer than what they were a few decades ago, and much safer than most people imagine”.
It’s worth reading the full article.